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The transcriptional nuclear factor kappaB (NF-kappaB)/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkappaB proteins. Activation occurs via phosphorylation of IkappaBalpha at Ser32 and Ser36, resulting in
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Transcription factors of the nuclear factor kappaB (NF-kappaB)/Rel family play a pivotal role in inflammatory and immune responses (1,2). There are five family members in mammals: RelA, RelB, c-Rel, NF-kappaB1 (p105/p50) and NF-kappaB2 (p100/p52). Both
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